Studies and Papers
Below are studies and papers on the cell danger response, probiotics, and more.
Cell Danger Response
The following three papers are from Dr. Robert Nauviaux.
Mitochondrial and Metabolic Features of Salugenesis and The Healing Cycle
Published in April of 2023 this paper is Dr. Robert Nauviaux’s most recent and most complete paper on what he has referred to as the cell danger response, the healing cycle, or salugenesis.
Metabolic Features and Regulation of the Healing Cycle—A New Model for Chronic Disease Pathogenesis and Treatment
This paper by Dr. Robert Naviaux demonstrates his work and findings on the cell danger response.
Metabolic Features of the Cell Danger Response
A paper by Dr. Robert Naviaux on the stages of the cell danger response.
Probiotics
The following studies and papers are on the impact of various probiotic or microbial strains of bacteria or yeast.
Lactobacillus casei-fermented blueberry pomace augments sIgA production in high-fat diet mice by improving intestinal microbiota
Screening of Indigenous Oxalate Degrading Lactic Acid Bacteria from Human Faeces and South Indian Fermented Foods: Assessment of Probiotic Potential
Lactobacillus fermentum TY5, Lactobacillus fermentum AB1, and Lactobacillus salivarius AB11 might be among the very best inigenous strains for degrading oxalates. And supplementation with them might be less transcient than many other strains.
Lactobacillus casei CRL 431 administration decreases inflammatory cytokines in a diet-induced obese mouse model
This study showed that Lactobacillus Casei CRL 431 administration reduced several inflammatory cytokines in the small intestine.
A pilot study investigating the effects of yakult fermented milk drink (L. casei Shirota) on salivary IFN-γ, sIgA, IgA1 and IgA2 in healthy volunteers
This study showed that administration of L. Casei Shirota increased SIgA levels in healthy adults.
Dietary Strategies to Promote the Abundance of Intestinal Akkermansia Muciniphila, a Focus on the Effect of Plant Extracts
Caffeic acid (coffee etc.), chlorogenic acid (coffee, berries, etc.), salvianolic acid (Chinese sage), proanthocyanidins (berries, grape, cranberry, cacao etc.), puerarin (kudzu root), resveratrol (grapes, blueberries, cacao, etc.), EGCG (tea), ellagitannins (berries, strawberries, blackberries, pomegranate, etc.), urolithin A (produced by gut microbes from ellagitannins and ellagic acid), Anthocyanins (berries, red cabbage, red onion, plums, eggplant etc.), and capsaicin (chili peppers) are all associated with increased levels of Akkermansia Muciniphilia.
Probiotic Lactobacillus Rhamnosus Downregulates FCER1 and HRH4 Expression in Human Mast Cells
This study suggests that supplementation solely with Lactobacillus rhamnosus and Lactobacillus rhamnosus GG could be an effective method to help manage mast cell activation syndromes.
Other Topics Related to the Healing Cycle
The following are papers and studies on topics related to the healing cycle.
Riboflavin, vitamin B2, attenuates NLRP3, NLRC4, AIM2, and non-canonical inflammasomes by the inhibition of caspase-1 activity
Riboflavin is critical in preventing and reducing the intensity of cell danger response.
Hypoxia inhibits colonic uptake of the microbiota-generated forms of vitamin B1 via HIF-1α-mediated transcriptional regulation of their transporters
Increasing oxygen levels of colonic cells (can be done via both increased blood flow or increased blood oxygen saturation) is critical to uptake of b1 in colonic cells and therefore prevention of or resolution of gastrointestinal beriberi.
Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention
This paper outlines the many potential benefits of PQQ including the improved intestinal barrier function, increased intestinal butyrate levels, enhancing mitochondrial function, and more.
Melatonin inhibits mast cell activation, indicating its potential as a therapeutic agent in inflammatory diseases
This study suggests melatonin may be a helpful option for those with MCAS.
α-Ketoglutarate Restores Intestinal Barrier Function through Promoting Intestinal Stem Cells-Mediated Epithelial Regeneration in Colitis
Can alpha-ketoglutarate supplementation increase cellular repair via increased stell cell action?
A Terminal Metabolite of Niacin Promotes Vascular Inflammation and Contributes to Cardiovascular Disease Risk
This study brings into question if metabolites of niacin might contribute to an increase in cardiovascular disease.
Fructan, Rather Than Gluten, Induces Symptoms in Patients With Self-Reported Non-Celiac Gluten Sensitivity
This study found that gluten surprisingly helped those with a self-reported gluten sensitivity but fructans (a prebiotic) were correlated with GI symptoms.
